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KMID : 0191120210360210157
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Journal of Korean Medical Science
2021 Volume.36 No. 21 p.157 ~ p.157
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Antibody Responses One Year after Mild SARS-CoV-2 Infection
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Choe Pyoeng-Gyun
Kim Kye-Hyung
Kang Chang-Kyung
Suh Hyeon-Jeong
Kang Eun-Kyo
Lee Sun-Young
Kim Nam-Joong
Yi Jong-Youn
Park Wan-Beom
Oh Myoung-Don
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Abstract
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Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.
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KEYWORD
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COVID-19, SARS-CoV-2, Antibody, ELISA, ECLIA
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